Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL, Siegel RL. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 2019;69:363–85.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.
Guo W, Chen Z, Tan L, Gu D, Ren X, Fu C, Wu Q, Meng X. Emerging biocompatible nanoplatforms for the potential application in diagnosis and therapy of deep tumors. View. 2022;3:20200174.
Dai Y, Xu C, Sun X, Chen X. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem Soc Rev. 2017;46:3830–52.
Mathew EN, Berry BC, Yang HW, Carroll RS, Johnson MD. Delivering therapeutics to glioblastoma: overcoming biological constraints. Int J Mol Sci. 2022;23:1711.
Tian HL, Zhang TT, Qin SY, Huang Z, Zhou L, Shi JY, Nice EC, Xie N, Huang CH, Shen ZS. Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. J Hematol Oncol. 2022;15:132.
Das CGA, Kumar VG, Dhas TS, Karthick V, Kumar CMV. Nanomaterials in anticancer applications and their mechanism of action- a review. Nanomed. 2023. https://doi.org/10.1016/j.nano.2022.102613.
Kapse-Mistry S, Govender T, Srivastava R, Yergeri M. Nanodrug delivery in reversing multidrug resistance in cancer cells. Front Pharmacol. 2014;5:159.
Li JN, Zhu LP, Kwok HF. Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resist Updat. 2023;66:100904.
Yan C-Y, Zhao M-L, Wei Y-N, Zhao X-H. Mechanisms of drug resistance in breast cancer liver metastases: dilemmas and opportunities. Mol Ther Oncolytics. 2023;28:212–29.
Zhu Y, Yu X, Thamphiwatana SD, Zheng Y, Pang Z. Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy. Acta Pharm Sin B. 2020;10:2054–74.
Silveira MJ, Castro F, Oliveira MJ, Sarmento B. Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored? Biomater Sci. 2021;9:3228–43.
Tie Y, Tang F, Wei YQ, Wei XW. Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets. J Hematol Oncol. 2022;15:61.
Xu YY, Xiong JY, Sun XY, Gao HL. Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy. Acta Pharm Sin B. 2022;12:4327–47.
Wei QY, Xu YM, Lau ATY. Recent progress of nanocarrier-based therapy for solid malignancies. Cancers. 2020;12:2783.
Yuan Y, Cai T, Xia X, Zhang R, Chiba P, Cai Y. Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer. Drug Deliv. 2016;23:3350–7.
Li XM, Li MD, Huang MY, Lin QY, Fang QP, Liu JJ, Chen XH, Liu L, Zhan XL, Shan HS, et al. The multi-molecular mechanisms of tumor-targeted drug resistance in precision medicine. Biomed Pharmacother. 2022;150:113064.
Liu M, Ren X, Liu X, Tan L, Li H, Wei J, Fu C, Wu Q, Ren J, Li H, Meng X. Luminescent silver nanoclusters for efficient detection of adenosine triphosphate in a wide range of pH values. Chin Chem Lett. 2020;31:3117–20.
Li S, Tan L, Meng X. Nanoscale metal-organic frameworks: synthesis, biocompatibility, imaging applications, and thermal and dynamic therapy of tumors. Adv Funct Mater. 2020;30:1908924.
Thanh NT, Maclean N, Mahiddine S. Mechanisms of nucleation and growth of nanoparticles in solution. Chem Rev. 2014;114:7610–30.
Sugimoto T. Underlying mechanisms in size control of uniform nanoparticles. J Colloid Interface Sci. 2007;309:106–18.
Jun YS, Zhu YG, Wang Y, Ghim D, Wu XH, Kim D, Jung H. Classical and nonclassical nucleation and growth mechanisms for nanoparticle formation. Annu Rev Phys Chem. 2022;73:453–77.
LaMer VK, Dinegar RH. Theory, production and mechanism of formation of Monodispersed Hydrosols. J Am Chem Soc. 1950;72:4847–54.
Hippolyte L, Sadek O, Ba Sowid S, Porcheron A, Bridonneau N, Blanchard S, Desage El Murr M, Gatineau D, Gimbert Y, Mercier D, et al. N-Heterocyclic carbene boranes: dual reagents for the synthesis of gold nanoparticles. Chemistry. 2023. https://doi.org/10.1002/chem.202301610.
Tran M, DePenning R, Turner M, Padalkar S. Effect of citrate ratio and temperature on gold nanoparticle size and morphology. Mater Res Express. 2016;3:105027.
Jeon Y, Thangadurai DT, Piao L, Yoon S. A facile one-step method to prepare size controlled Fe3O4 submicro/nanoparticles. Mater Lett. 2013;96:27–30.
Mayer F, Peters JA, Djanashvili K. Microwave-assisted seeded growth of lanthanide-based nanoparticles for imaging and therapy. Chemistry. 2012;18:8004–7.
Komoda K, Kawauchi T. Size-controlled one-pot synthesis of viologen nanoparticles via a microwave heating technique. Polym J. 2021;53:937–42.
Idris AH, Abdullah CAC, Yusof NA, Rahman MBA. One-pot synthesis of iron oxide nanoparticles: effect of stirring rate and reaction time on its physical characteristics. Inorg Nano-Met Chem. 2022. https://doi.org/10.1080/24701556.2022.2072339.
Vreeland EC, Watt J, Schober GB, Hance BG, Austin MJ, Price AD, Fellows BD, Monson TC, Hudak NS, Maldonado-Camargo L, et al. Enhanced nanoparticle size control by extending LaMer’s mechanism. Chem Mater. 2015;27:6059–66.
Yuan J, Yao G, Pan S, Murali N, Li X. Size control of in situ synthesized TiB2 particles in molten aluminum. Metall Mater Trans A. 2021;52:2657–66.
Mott D, Galkowski J, Wang LY, Luo J, Zhong CJ. Synthesis of size-controlled and shaped copper nanoparticles. Langmuir. 2007;23:5740–5.
Rao JP, Geckeler KE. Polymer nanoparticles: preparation techniques and size-control parameters. Prog Polym Sci. 2011;36:887–913.
Lai P, Daear W, Lobenberg R, Prenner EJ. Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate. Colloids Surf B. 2014;118:154–63.
Khan SA, Schneider M. Improvement of nanoprecipitation technique for preparation of gelatin nanoparticles and potential macromolecular drug loading. Macromol Biosci. 2013;13:455–63.
Lince F, Marchisio DL, Barresi AA. Strategies to control the particle size distribution of poly-epsilon-caprolactone nanoparticles for pharmaceutical applications. J Colloid Interface Sci. 2008;322:505–15.
D’Addio SM, Prud’homme RK. Controlling drug nanoparticle formation by rapid precipitation. Adv Drug Deliv Rev. 2011;63:417–26.
Beck-Broichsitter M, Nicolas J, Couvreur P. Solvent selection causes remarkable shifts of the “Ouzo region” for poly(lactide-co-glycolide) nanoparticles prepared by nanoprecipitation. Nanoscale. 2015;7:9215–21.
Zweers ML, Grijpma DW, Engbers GH, Feijen J. The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size. J Biomed Mater Res Part B Appl Biomater. 2003;66:559–66.
Reisch A, Runser A, Arntz Y, Mély Y, Klymchenko AS. Charge-controlled nanoprecipitation as a modular approach to ultrasmall polymer nanocarriers: making bright and stable nanoparticles. ACS Nano. 2015;9:5104–16.
Rosiuk V, Runser A, Klymchenko A, Reisch A. Controlling size and fluorescence of dye-loaded polymer nanoparticles through Polymer Design. Langmuir. 2019;35:7009–17.
Ichihashi K, Muratsugu S, Miyamoto S, Sakamoto K, Ishiguro N, Tada M. Enhanced oxygen reduction reaction performance of size-controlled pt nanoparticles on polypyrrole-functionalized carbon nanotubes. Dalton Trans. 2019;48:7130–7.
Kim SW, Park J, Jang Y, Chung Y, Hwang S, Hyeon T, Kim YW. Synthesis of monodisperse palladium nanoparticles. Nano Lett. 2003;3:1289–91.
Mayer CR, Dumas E, Secheresse F. Size controlled formation of silver nanoparticles by direct bonding of ruthenium complexes bearing a terminal mono- or bi-pyridyl group. ChemComm 2005:345–7.
Onita K, Onishi M, Omura T, Wakiya T, Suzuki T, Minami H. Preparation of Monodisperse Bio-Based polymer particles via dispersion polymerization. Langmuir. 2022;38:7341–5.
Niyom Y, Phakkeeree T, Flood A, Crespy D. Synergy between polymer crystallinity and nanoparticles size for payloads release. J Colloid Interface Sci. 2019;550:139–46.
Benita S, Benoit JP, Puisieux F, Thies C. Characterization of drug-loaded poly(d,l-lactide) Microspheres. J Pharm Sci. 1984;73:1721–4.
Barhoum A, Rahier H, Abou-Zaied RE, Rehan M, Dufour T, Hill G, Dufresne A. Effect of cationic and anionic surfactants on the application of calcium carbonate nanoparticles in paper coating. ACS Appl Mater Interfaces. 2014;6:2734–44.
Rahman IA, Padavettan V. Synthesis of silica nanoparticles by Sol-Gel: size-dependent Properties, Surface Modification, and applications in silica-polymer Nanocomposites—A review. J Nanomater. 2012;2012:1–15.
Li XW, Song RG, Jiang Y, Wang C, Jiang D. Surface modification of TiO2 nanoparticles and its effect on the properties of fluoropolymer/TiO2 nanocomposite coatings. Appl Surf Sci. 2013;276:761–8.
Li D, Sun G, Ouyang X, Zhong P, Wang S. Surface modification of alumina nanoparticles and its application in tape casting of micro-nano green tape. Appl Surf Sci. 2023;622:156963.
Hong RY, Li JH, Chen LL, Liu DQ, Li HZ, Zheng Y, Ding J. Synthesis, surface modification and photocatalytic property of ZnO nanoparticles. Powder Technol. 2009;189:426–32.
Barabanova AI, Pryakhina TA, Afanas’ev ES, Zavin BG, Vygodskii YS, Askadskii AA, Philippova OE, Khokhlov AR. Anhydride modified silica nanoparticles: Preparation and characterization. Appl Surf Sci. 2012;258:3168–72.
Keleştemur S, Altunbek M, Culha M. Influence of EDC/NHS coupling chemistry on stability and cytotoxicity of ZnO nanoparticles modified with proteins. Appl Surf Sci. 2017;403:455–63.
Oster G, Shibata O. Graft copolymer of polyacrylamide and natural rubber produced by means of ultraviolet light. J Polym Sci. 1957;26:233–4.
Kim S, Kim E, Kim S, Kim W. Surface modification of silica nanoparticles by UV-induced graft polymerization of methyl methacrylate. J Colloid Interface Sci. 2005;292:93–8.
Lou Y, Schapman D, Mercier D, Alexandre S, Burel F, Thebault P, Kébir N. Preparation of bactericidal surfaces with high quaternary ammonium content through photo-initiated polymerization of N-[2-(acryloyloxy)ethyl]-N,N-dimethyl-N-butylammonium iodide from native and thiolated PDMS surfaces. React Funct Polym. 2021;165:104941.
Tomovska R, Daniloska V, Asua JM. UV/Vis photocatalytic functionalization of TiO2 nanoparticle surfaces toward water repellent properties. J Mater Chem. 2011;21:17492–7.
Tomovska R, Daniloska V, Asua JM. Surface modification of TiO2 nanoparticles via photocataliticaly induced reaction: influence of functionality of silane coupling agent. Appl Surf Sci. 2013;264:670–3.
Ju J, Wang T, Wang Q. Superhydrophilic and underwater superoleophobic PVDF membranes via plasma-induced surface PEGDA for effective separation of oil-in-water emulsions. Colloids Surf A Physicochem Eng Asp. 2015;481:151–7.
Kiatkamjornwong S, Mongkolsawat K, Sonsuk M. Synthesis and property characterization of cassava starch grafted poly[acrylamide-co-(maleic acid)] superabsorbent via γ-irradiation. Polymer. 2002;43:3915–24.
Kumar R, Sharma K, Tiwary KP, Sen G. Polymethacrylic acid grafted psyllium (Psy-g-PMA): a novel material for waste water treatment. App Water Sci. 2013;3:285–91.
Szwarc M. ‘Living’ Polym Nat. 1956;178:1168–9.
Moad G, Rizzardo E, Thang SH. Toward living radical polymerization. Acc Chem Res. 2008;41:1133–42.
Matyjaszewski K, Dong HC, Jakubowski W, Pietrasik J, Kusumo A. Grafting from surfaces for “Everyone”: ARGET ATRP in the presence of air. Langmuir. 2007;23:4528–31.
Park JT, Seo JA, Ahn SH, Kim JH, Kang SW. Surface modification of silica nanoparticles with hydrophilic polymers. J Ind Eng Chem. 2010;16:517–22.
Guo C, Yu Y, Jiang X, Ma B, Liu Z, Chai Y, Wang L, Wang B, Du Y, Li N, et al. Photorenewable Azobenzene Polymer Brush-Modified nanoadsorbent for selective adsorption of LDL in serum. ACS Appl Mater Interfaces. 2022;14:34388–99.
Cazotti JC, Fritz AT, Garcia-Valdez O, Smeets NMB, Dube MA, Cunningham MF. Graft modification of Starch Nanoparticles using nitroxide-mediated polymerization and the “Grafting to” Approach. Biomacromolecules. 2020;21:4492–501.
Tumnantong D, Rempel GL, Prasassarakich P. Synthesis of polystyrene-silica nanoparticles via RAFT emulsifier-free emulsion polymerization. Eur Polym J. 2016;80:145–57.
Xing Y, Li Q, Chen X, Li M, Wang S, Li Y, Wang T, Sun X, Li X. Preparation of isoelectric point-switchable polymer brush-grafted mesoporous silica using RAFT polymerization with high performance for Ni(II) adsorption. Powder Technol. 2022;412:117980.
Ren X, Wang M, He X, Li Z, Zhang J, Zhang W, Chen X, Ren H, Meng X. Superoxide dismutase mimetic ability of Mn-doped ZnS QDs. Chin Chem Lett. 2018;29:1865–8.
Liu R, Priestley RD. Rational design and fabrication of core–shell nanoparticles through a one-step/pot strategy. J Mater Chem A. 2016;4:6680–92.
Yang Y, Zeng ZT, Almatrafi E, Huang DL, Zhang C, Xiong WP, Cheng M, Zhou CY, Wang WJ, Song BA, et al. Core-shell structured nanoparticles for photodynamic therapy-based cancer treatment and related imaging. Coord Chem Rev. 2022. https://doi.org/10.1016/j.ccr.2022.214427.
El-Toni AM, Habila MA, Labis JP, ZA AL, Alhoshan M, Elzatahry AA, Zhang F. Design, synthesis and applications of core-shell, hollow core, and nanorattle multifunctional nanostructures. Nanoscale. 2016;8:2510–31.
Gao M, Zhu L, Ong WL, Wang J, Ho GW. Structural design of TiO2-based photocatalyst for H2 production and degradation applications. Catal Sci Technol. 2015;5:4703–26.
Li Y, Yi R, Yan A, Deng L, Zhou K, Liu X. Facile synthesis and properties of ZnFe2O4 and ZnFe2O4/polypyrrole core-shell nanoparticles. Solid State Sci. 2009;11:1319–24.
Serpell CJ, Cookson J, Ozkaya D, Beer PD. Core@shell bimetallic nanoparticle synthesis via anion coordination. Nat Chem. 2011;3:478–83.
Wan Y, Min YL, Yu SH. Synthesis of silica/carbon-encapsulated core-shell spheres: templates for other unique core-shell structures and applications in in situ loading of noble-metal nanoparticles. Langmuir. 2008;24:5024–8.
Liu B, Wang Q, Yu S, Zhao T, Han J, Jing P, Hu W, Liu L, Zhang J, Sun LD, Yan CH. Double shelled hollow nanospheres with dual noble metal nanoparticle encapsulation for enhanced catalytic application. Nanoscale. 2013;5:9747–57.
Lin LS, Song J, Yang HH, Chen X. Yolk-Shell Nanostructures: design, synthesis, and Biomedical Applications. Adv Mater. 2018;30:1704639.
Si MY, Lin F, Ni HL, Wang SS, Lu YN, Meng XY. Research progress of yolk-shell structured nanoparticles and their application in catalysis. Rsc Adv. 2023;13:2140–54.
Nikravan G, Haddadi-Asl V, Salami-Kalajahi M. Synthesis of dual temperature – and pH-responsive yolk-shell nanoparticles by conventional etching and new deswelling approaches: DOX release behavior. Colloids Surf B. 2018;165:1–8.
Wang Y, Li L, Wang C, Wang T. Facile approach to synthesize uniform Au@mesoporous SnO2 yolk–shell nanoparticles and their excellent catalytic activity in 4-nitrophenol reduction. J Nanopart Res. 2015;18:2.
Liu J, Qiao SZ, Budi Hartono S, Lu GQ. Monodisperse yolk-shell nanoparticles with a hierarchical porous structure for delivery vehicles and nanoreactors. Angew Chem Int Ed. 2010;49:4981–5.
Du X, Zhao C, Luan Y, Zhang C, Jaroniec M, Huang H, Zhang X, Qiao S-Z. Dendritic porous yolk@ordered mesoporous shell structured heterogeneous nanocatalysts with enhanced stability. J Mater Chem A. 2017;5:21560–9.
Leng J, Wang Z, Li X, Guo H, Li H, Shih K, Yan G, Wang J. Accurate construction of a hierarchical nickel–cobalt oxide multishell yolk–shell structure with large and ultrafast lithium storage capability. J Mater Chem A. 2017;5:14996–5001.
Feng Y, Qiu H, Gao Y, Zheng H, Tan J. Creative design for sandwich structures: a review. Int J Adv Robot Syst. 2020;17:1729881420921327.
Xiong J, Du Y, Mousanezhad D, Eydani Asl M, Norato J, Vaziri A. Sandwich structures with prismatic and Foam Cores: a review. Adv Eng Mater. 2019;21:1800036.
Lv W, Sun F, Tang D-M, Fang H-T, Liu C, Yang Q-H, Cheng H-M. A sandwich structure of graphene and nickel oxide with excellent supercapacitive performance. J Mater Chem. 2011;21:9014–9.
Heidari EK, Zhang B, Sohi MH, Ataie A, Kim J-K. Sandwich-structured graphene–NiFe2O4–carbon nanocomposite anodes with exceptional electrochemical performance for Li ion batteries. J Mater Chem A. 2014;2:8314–22.
Guo R, Jiao T, Li R, Chen Y, Guo W, Zhang L, Zhou J, Zhang Q, Peng Q. Sandwiched Fe3O4/Carboxylate Graphene Oxide Nanostructures constructed by layer-by-Layer Assembly for highly efficient and magnetically recyclable dye removal. ACS Sustain Chem Eng. 2017;6:1279–88.
Lv Y, Duan S, Wang R. Structure design, controllable synthesis, and application of metal-semiconductor heterostructure nanoparticles. Prog Nat Sci. 2020;30:1–12.
Xiong W, Sikdar D, Yap LW, Premaratne M, Li X, Cheng W. Multilayered core-satellite nanoassemblies with fine-tunable broadband plasmon resonances. Nanoscale. 2015;7:3445–52.
Han F, Vivekchand SRC, Soeriyadi AH, Zheng Y, Gooding JJ. Thermoresponsive plasmonic core-satellite nanostructures with reversible, temperature sensitive optical properties. Nanoscale. 2018;10:4284–90.
Ma M, Yan F, Yao M, Wei Z, Zhou D, Yao H, Zheng H, Chen H, Shi J. Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules toward magnetic resonance imaging-guided high-intensity focused ultrasound therapy. ACS Appl Mater Interfaces. 2016;8:29986–96.
Jhaveri A, Deshpande P, Torchilin V. Stimuli-sensitive nanopreparations for combination cancer therapy. J Control Release. 2014;190:352–70.
Kobayashi H, Watanabe R, Choyke PL. Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target? Theranostics. 2013;4:81–9.
Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs1. Cancer Res. 1986;46:6387–92.
Yu X, Trase I, Ren M, Duval K, Guo X, Chen Z. Design of nanoparticle-based carriers for targeted drug delivery. J Nanomater. 2016;2016:1–15.
Li Y, Kroger M, Liu WK. Endocytosis of PEGylated nanoparticles accompanied by structural and free energy changes of the grafted polyethylene glycol. Biomaterials. 2014;35:8467–78.
Liu R, Xiao W, Hu C, Xie R, Gao H. Theranostic size-reducible and no donor conjugated gold nanocluster fabricated hyaluronic acid nanoparticle with optimal size for combinational treatment of breast cancer and lung metastasis. J Control Release. 2018;278:127–39.
Kim HL, Lee SB, Jeong HJ, Kim DW. Enhanced tumor targetability of PEGylated mesoporous silica nanoparticles on in vivo optical imaging according to their size. RSC Adv. 2014;4:31318–22.
Bai S, Zhang Y, Li D, Shi X, Lin G, Liu G. Gain an advantage from both sides: smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration. Nano Today. 2021;36:101038.
Wang J, Asghar S, Jin X, Chen Z, Huang L, Ping Q, Zong L, Xiao Y. Mitoxantrone-loaded chitosan/hyaluronate polyelectrolyte nanoparticles decorated with amphiphilic PEG derivates for long-circulating effect. Colloids Surf B. 2018;171:468–77.
Gao H, Xiong J, Cheng T, Liu J, Chu L, Liu J, Ma R, Shi L. In vivo biodistribution of mixed shell micelles with tunable hydrophilic/hydrophobic surface. Biomacromolecules. 2013;14:460–7.
Ou H, Cheng T, Zhang Y, Liu J, Ding Y, Zhen J, Shen W, Xu Y, Yang W, Niu P, et al. Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells. Acta Biomater. 2018;65:339–48.
Liu WC, Yan QW, Xia C, Wang XX, Kumar A, Wang Y, Liu YW, Pan Y, Liu JQ. Recent advances in cell membrane coated metal-organic frameworks (MOFs) for tumor therapy. J Mater Chem B. 2021;9:4459–74.
Oldenborg P-A, Zheleznyak A, Fang Y-F, Lagenaur CF, Gresham HD, Lindberg FP. Role of CD47 as a marker of self on Red Blood cells. Science. 2000;288:2051–4.
Su J, Sun H, Meng Q, Yin Q, Tang S, Zhang P, Chen Y, Zhang Z, Yu H, Li Y. Long circulation red-blood-cell-mimetic nanoparticles with peptide-enhanced tumor penetration for simultaneously inhibiting growth and lung metastasis of breast Cancer. Adv Funct Mater. 2016;26:1243–52.
Chen Y, Xu PF, Wu MY, Meng QS, Chen HR, Shu Z, Wang J, Zhang LX, Li YP, Shi JL. Colloidal RBC-Shaped, hydrophilic, and hollow mesoporous carbon nanocapsules for highly efficient biomedical engineering. Adv Mater. 2014;26:4294–301.
Doshi N, Zahr AS, Bhaskar S, Lahann J, Mitragotri S. Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci USA. 2009;106:21495–9.
Fang J, Nakamura H, Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev. 2011;63:136–51.
Sultana S, Khan MR, Kumar M, Kumar S, Ali M. Nanoparticles-mediated drug delivery approaches for cancer targeting: a review. J Drug Target. 2013;21:107–25.
Dutta B, Barick KC, Hassan PA. Recent advances in active targeting of nanomaterials for anticancer drug delivery. Adv Colloid Interface Sci. 2021;296:102509.
Shi P, Cheng Z, Zhao K, Chen Y, Zhang A, Gan W, Zhang Y. Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics. J Nanobiotechnol. 2023;21:103.
Sudimack J, Lee RJ. Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev. 2000;41:147–62.
Nawaz FZ, Kipreos ET. Emerging roles for folate receptor FOLR1 in signaling and cancer. Trends Endocrinol Metab. 2022;33:159–74.
Ramalho MJ, Loureiro JA, Coelho MAN, Pereira MC. Transferrin receptor-targeted nanocarriers: overcoming barriers to treat Glioblastoma. Pharmaceutics. 2022;14:279.
Halder S, Basu S, Lall SP, Ganti AK, Batra SK, Seshacharyulu P. Targeting the EGFR signaling pathway in cancer therapy: what’s new in 2023? Expert Opin. Ther Targets. 2023;27:305–24.
Zhang XN, Gao Y, Zhang XY, Guo NJ, Hou WQ, Wang SW, Zheng YC, Wang N, Liu HM, Wang B. Detailed curriculum vitae of HER2-targeted therapy. Pharmacol Ther. 2023;245:108417.
Xu HX, Niu MK, Yuan X, Wu KM, Liu AG. CD44 as a tumor biomarker and therapeutic target. Exp Hematol Oncol. 2020;9:36.
Jurczyk M, Jelonek K, Musial-Kulik M, Beberok A, Wrzesniok D, Kasperczyk J. Single- versus dual-targeted nanoparticles with folic acid and biotin for Anticancer Drug Delivery. Pharmaceutics. 2021;13:326.
Egorova EA, Nikitin MP. Delivery of theranostic nanoparticles to various cancers by means of integrin-binding peptides. Int J Mol Sci. 2022;23:13735.
Chen Z, Kankala RK, Long L, Xie S, Chen A, Zou L. Current understanding of passive and active targeting nanomedicines to enhance tumor accumulation. Coord Chem Rev. 2023. https://doi.org/10.1016/j.ccr.2023.215051.
Elnaggar MH, Abushouk AI, Hassan AHE, Lamloum HM, Benmelouka A, Moatamed SA, Abd-Elmegeed H, Attia S, Samir A, Amr N, et al. Nanomedicine as a putative approach for active targeting of hepatocellular carcinoma. Semin Cancer Biol. 2021;69:91–9.
Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010;141:52–67.
Xue CC, Li MH, Zhao Y, Zhou J, Hu Y, Cai KY, Zhao YL, Yu SH, Luo Z. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Sci Adv. 2020;6:eaax1346.
He X, Wang D, Chen P, Qiao YB, Yang TH, Yu Z, Wang CL, Wu H. Construction of a novel “ball-and-rod” MSNs-pp-PEG system: a promising antitumor drug delivery system with a particle size switchable function. ChemComm. 2020;56:4785–8.
Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med. 2001;30:1191–212.
Mirhadi E, Mashreghi M, Faal Maleki M, Alavizadeh SH, Arabi L, Badiee A, Jaafari MR. Redox-sensitive nanoscale drug delivery systems for cancer treatment. Int J Pharm. 2020;589:119882.
Cheng R, Meng F, Deng C, Klok HA, Zhong Z. Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. Biomaterials. 2013;34:3647–57.
Li K, Lin CC, He Y, Lu L, Xu K, Tao BL, Xia ZZL, Zeng R, Mao YL, Luo Z, Cai KY. Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for enhanced Tumor Chemo-Immunotherapy. ACS Nano. 2020;14:14164–80.
Chen G, Ma B, Wang Y, Gong S. A Universal GSH-Responsive Nanoplatform for the delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein. ACS Appl Mater Interfaces. 2018;10:18515–23.
Cheng XT, Xu HD, Ran HH, Liang GL, Wu FG. Glutathione-depleting nanomedicines for synergistic Cancer therapy. ACS Nano. 2021;15:8039–68.
Wu Q, Du QJ, Sun XH, Niu M, Tan LF, Fu CH, Ren XL, Zheng YJ, Liang TS, Zhao JY, et al. MnMOF-based microwave-glutathione dual-responsive nano-missile for enhanced microwave Thermo-dynamic chemotherapy of drug-resistant tumors. Chem Eng J. 2022;439:135582.
Xie M, Zhu Y, Xu S, Xu G, Xiong R, Sun X, Liu C. A nanoplatform with tumor-targeted aggregation and drug-specific release characteristics for photodynamic/photothermal combined antitumor therapy under near-infrared laser irradiation. Nanoscale. 2020;12:11497–509.
Zhang X, Lu H, Tang N, Chen A, Wei Z, Cao R, Zhu Y, Lin L, Li Q, Wang Z, Tian L. Low-power magnetic resonance-guided focused ultrasound tumor ablation upon controlled accumulation of magnetic nanoparticles by cascade-activated DNA cross-linkers. ACS Appl Mater Interfaces. 2022;14:31677–88.
Bhavsar DB, Patel V, Sawant KK. Design and characterization of dual responsive mesoporous silica nanoparticles for breast cancer targeted therapy. Eur J Pharm Sci. 2020;152:105428.
Chorny M, Fishbein I, Yellen BB, Alferiev IS, Bakay M, Ganta S, Adamo R, Amiji M, Friedman G, Levy RJ. Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc Natl Acad Sci USA. 2010;107:8346–51.
Wang Y, Li B, Zhang L, Song H, Zhang L. Targeted delivery system based on magnetic mesoporous silica nanocomposites with light-controlled release character. ACS Appl Mater Interfaces. 2013;5:11–5.
Liu C, Ewert KK, Yao W, Wang N, Li Y, Safinya CR, Qiao W. A multifunctional lipid incorporating active targeting and dual-control release capabilities for Precision Drug Delivery. ACS Appl Mater Interfaces. 2019;12:70–85.
Boumahdi S, de Sauvage FJ. The great escape: tumour cell plasticity in resistance to targeted therapy. Nat Rev Drug Discov. 2020;19:39–56.
Cabanos HF, Hata AN. Emerging insights into targeted therapy-tolerant Persister cells in Cancer. Cancer. 2021;13:714–26.
Gavas S, Quazi S, Karpinski TM. Nanoparticles for cancer therapy: current progress and challenges. Nanoscale Res Lett. 2021;16:173.
Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG. Cancer drug resistance: an evolving paradigm. Nat Rev Cancer. 2013;13:714–26.
Ling D, Park W, Park SJ, Lu Y, Kim KS, Hackett MJ, Kim BH, Yim H, Jeon YS, Na K, Hyeon T. Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J Am Chem Soc. 2014;136:5647–55.
Su Z, Dong S, Zhao SC, Liu K, Tan Y, Jiang X, Assaraf YG, Qin B, Chen ZS, Zou C. Novel nanomedicines to overcome cancer multidrug resistance. Drug Resist Updat. 2021;58:100777.
Fulfager AD, Yadav KS. Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer. J Drug Deliv Sci Technol. 2021;62:102405.
Guo Y, Wang M, Zou Y, Jin L, Zhao Z, Liu Q, Wang S, Li J. Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer. J Nanobiotechnol. 2022;20:371.
Haider M, Elsherbeny A, Pittala V, Consoli V, Alghamdi MA, Hussain Z, Khoder G, Greish K. Nanomedicine strategies for management of Drug Resistance in Lung Cancer. Int J Mol Sci. 2022;23:1853.
McGranahan N, Swanton C. Clonal heterogeneity and tumor evolution: past, present, and the future. Cell. 2017;168:613–28.
Shibue T, Weinberg RA. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications. Nat Rev Clin Oncol. 2017;14:611–29.
Khdair A, Chen D, Patil Y, Ma L, Dou QP, Shekhar MP, Panyam J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance. J Control Release. 2010;141:137–44.
Wang Q, Zhang X, Liao H, Sun Y, Ding L, Teng Y, Zhu W-H, Zhang Z, Duan Y. Multifunctional Shell-Core Nanoparticles for treatment of Multidrug Resistance Hepatocellular Carcinoma. Adv Funct Mater. 2018;28:1706124.
Bareford LM, Swaan PW. Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev. 2007;59:748–58.
Kirtane AR, Kalscheuer SM, Panyam J. Exploiting nanotechnology to overcome tumor drug resistance: challenges and opportunities. Adv Drug Deliv Rev. 2013;65:1731–47.
Hu L, Xiong C, Wei G, Yu Y, Li S, Xiong X, Zou JJ, Tian J. Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer. J Colloid Interface Sci. 2022;608:1882–93.
Cao ZT, Chen ZY, Sun CY, Li HJ, Wang HX, Cheng QQ, Zuo ZQ, Wang JL, Liu YZ, Wang YC, Wang J. Overcoming tumor resistance to cisplatin by cationic lipid-assisted prodrug nanoparticles. Biomaterials. 2016;94:9–19.
Wang Q, Zou C, Wang L, Gao X, Wu J, Tan S, Wu G. Doxorubicin and adjudin co-loaded pH-sensitive nanoparticles for the treatment of drug-resistant cancer. Acta Biomater. 2019;94:469–81.
Wartenberg M, Fischer K, Hescheler J, Sauer H. Redox regulation of P-glycoprotein-mediated multidrug resistance in multicellular prostate tumor spheroids. Int J Cancer. 2000;85:267–74.
Wartenberg M, Ling FC, Schallenberg M, Baumer AT, Petrat K, Hescheler J, Sauer H. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J Biol Chem. 2001;276:17420–8.
Ye M, Han Y, Tang J, Piao Y, Liu X, Zhou Z, Gao J, Rao J, Shen Y. A tumor-specific cascade amplification drug release nanoparticle for overcoming multidrug resistance in cancers. Adv Mater. 2017;29:1702342.
Wu C, Gong MQ, Liu BY, Zhuo RX, Cheng SX. Co-delivery of multiple drug resistance inhibitors by polymer/inorganic hybrid nanoparticles to effectively reverse cancer drug resistance. Colloids Surf B. 2017;149:250–9.
Lee SM, Kim HJ, Kim SY, Kwon MK, Kim S, Cho A, Yun M, Shin JS, Yoo KH. Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer. Biomaterials. 2014;35:2272–82.
Guo J, Tan D, Lou C, Guo S, Jin X, Qu H, Jing L, Li S. A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors. Bioact Mater. 2022;9:554–65.
Ma X, Wu Q, Tan L, Fu C, Ren X, Du Q, Chen L, Meng X. Chemical chaperone delivered nanoscale metal–organic frameworks as inhibitor of endoplasmic reticulum for enhanced sensitization of thermo-chemo therapy. Chin Chem Lett. 2022;33:1604–8.
Deng Y, Käfer F, Chen T, Jin Q, Ji J, Agarwal S. Let there be light: polymeric Micelles with Upper critical solution temperature as light-triggered heat nanogenerators for combating drug-resistant Cancer. Small. 2018;14:1802420.
Wartenberg M, Ling FC, Muschen M, Klein F, Acker H, Gassmann M, Petrat K, Putz V, Hescheler J, Sauer H. Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J. 2003;17:503–5.
Tian H, Luo Z, Liu L, Zheng M, Chen Z, Ma A, Liang R, Han Z, Lu C, Cai L. Cancer Cell membrane-biomimetic oxygen nanocarrier for breaking Hypoxia-Induced Chemoresistance. Adv Funct Mater. 2017;27:1703197.
Zan Y, Dai Z, Liang L, Deng Y, Dong L. Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment. Drug Deliv. 2019;26:1080–91.
Chen ZZ, Niu M, Chen G, Wu Q, Tan LF, Fu CH, Ren XL, Zhong HS, Xu K, Meng XW. Oxygen production of modified core-shell CuO@ZrO2 nanocomposites by microwave radiation to alleviate cancer hypoxia for enhanced chemo-microwave thermal therapy. ACS Nano. 2018;12:12721–32.
Chen ZZ, Guo WN, Wu Q, Tan LF, Ma TC, Fu CH, Yu J, Ren XL, Wang JM, Liang P, Meng XW. Tumor reoxygenation for enhanced combination of radiation therapy and microwave thermal therapy using oxygen generation in situ by CuO nanosuperparticles under microwave irradiation. Theranostics. 2020;10:4659–75.
Patil YB, Swaminathan SK, Sadhukha T, Ma L, Panyam J. The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance. Biomaterials. 2010;31:358–65.
Shen S, Xu X, Lin S, Zhang Y, Liu H, Zhang C, Mo R. A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells. Nat Nanotechnol. 2021;16:104–13.
Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, Tang F, Chen ZQ, Liu XP, Xu ZD. Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res. 2009;15:2657–65.
Guo Z, Zheng K, Tan Z, Liu Y, Zhao Z, Zhu G, Ma K, Cui C, Wang L, Kang T. Overcoming drug resistance with functional mesoporous titanium dioxide nanoparticles combining targeting, drug delivery and photodynamic therapy. J Mater Chem B. 2018;6:7750–9.
Kapitanova KS, Naumenko VA, Garanina AS, Melnikov PA, Abakumov MA, Alieva IB. Advances and Challenges of nanoparticle-based macrophage reprogramming for Cancer Immunotherapy. Biochemistry. 2019;84:729–45.
Shen L, Li J, Liu Q, Song W, Zhang X, Tiruthani K, Hu H, Das M, Goodwin TJ, Liu R, Huang L. Local blockade of Interleukin 10 and C-X-C motif chemokine ligand 12 with nano-delivery promotes antitumor response in murine cancers. ACS Nano. 2018;12:9830–41.
Wang S, Zhao X, Wu S, Cui D, Xu Z. Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies. Biomark Res. 2023;11:34.
Ren X, Huang X, Wu Q, Tan L, Fu C, Chen Y, Meng X. Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2. Chin Chem Lett. 2021;32:3087–9.
Domvri K, Petanidis S, Anestakis D, Porpodis K, Bai C, Zarogoulidis P, Freitag L, Hohenforst-Schmidt W, Katopodi T. Dual photothermal MDSCs-targeted immunotherapy inhibits lung immunosuppressive metastasis by enhancing T-cell recruitment. Nanoscale. 2020;12:7051–62.
Song X, Xu J, Liang C, Chao Y, Jin Q, Wang C, Chen M, Liu Z. Self-supplied tumor oxygenation through separated liposomal delivery of H2O2 and catalase for enhanced radio-immunotherapy of Cancer. Nano Lett. 2018;18:6360–8.
Feng C, Xiong Z, Wang C, Xiao W, Xiao H, Xie K, Chen K, Liang H, Zhang X, Yang H. Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis. Bioact Mater. 2021;6:963–74.
Li L, Zhen M, Wang H, Sun Z, Jia W, Zhao Z, Zhou C, Liu S, Wang C, Bai C. Functional Gadofullerene Nanoparticles trigger Robust Cancer Immunotherapy based on rebuilding an immunosuppressive Tumor Microenvironment. Nano Lett. 2020;20:4487–96.
Sun X, Cao Z, Mao K, Wu C, Chen H, Wang J, Wang X, Cong X, Li Y, Meng X, et al. Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib. Biomaterials. 2020;240:119845.
Wen M, Ouyang J, Wei C, Li H, Chen W, Liu YN. Artificial enzyme catalyzed cascade reactions: antitumor immunotherapy reinforced by NIR-II light. Angew Chem Int Ed. 2019;58:17425–32.
Qi J, Li W, Lu K, Jin F, Liu D, Xu X, Wang X, Kang X, Wang W, Shu G, et al. pH and thermal dual-sensitive nanoparticle-mediated synergistic Antitumor Effect of Immunotherapy and Microwave Thermotherapy. Nano Lett. 2019;19:4949–59.
Wei B, Pan J, Yuan R, Shao B, Wang Y, Guo X, Zhou S. Polarization of tumor-associated macrophages by nanoparticle-loaded Escherichia coli combined with immunogenic cell death for Cancer Immunotherapy. Nano Lett. 2021;21:4231–40.
Zhao Y, Song Q, Yin Y, Wu T, Hu X, Gao X, Li G, Tan S, Zhang Z. Immunochemotherapy mediated by thermosponge nanoparticles for synergistic anti-tumor effects. J Control Release. 2018;269:322–36.
Yu W, He X, Yang Z, Yang X, Xiao W, Liu R, Xie R, Qin L, Gao H. Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis. Biomaterials. 2019;217:119309.
Wang DG, Wang TT, Yu HJ, Feng B, Zhou L, Zhou FY, Hou B, Zhang HW, Luo M, Li YP. Engineering nanoparticles to locally activate T cells in the tumor microenvironment. Sci Immunol. 2019;4:eaau6584.
Kang M, Hong J, Jung M, Kwon SP, Song SY, Kim HY, Lee JR, Kang S, Han J, Koo JH, et al. T-Cell-mimicking nanoparticles for Cancer Immunotherapy. Adv Mater. 2020;32:e2003368.
Huang YH, Kim BYS, Chan CK, Hahn SM, Weissman IL, Jiang W. Improving immune-vascular crosstalk for cancer immunotherapy. Nat Rev Immunol. 2018;18:195–203.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, et al. Mitochondrial akt regulation of hypoxic tumor reprogramming. Cancer Cell. 2016;30:257–72.
Wang J, Liu L, You Q, Song Y, Sun Q, Wang Y, Cheng Y, Tan F, Li N. All-in-one theranostic nanoplatform based on hollow mosx for photothermally-maneuvered oxygen self-enriched photodynamic therapy. Theranostics. 2018;8:955–71.
Zhao LR, Fu CH, Tan LF, Li T, Zhong HS, Meng XW. Advanced nanotechnology for hypoxia-associated antitumor therapy. Nanoscale. 2020;12:2855–74.
Yang Z, Gao D, Guo X, Jin L, Zheng J, Wang Y, Chen S, Zheng X, Zeng L, Guo M, et al. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets. ACS Nano. 2020;14:17442–57.
Kim H, Cha J, Jang M, Kim P. Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage. Biomater Sci. 2019;7:2264–71.
Shi Q, Zhao L, Xu C, Zhang L, Zhao H. High Molecular Weight Hyaluronan suppresses macrophage M1 polarization and enhances IL-10 production in PM2.5-Induced Lung inflammation. Molecules. 2019;24:1766.
Huang H, Jiang CT, Shen S, Liu A, Gan YJ, Tong QS, Chen SB, Gao ZX, Du JZ, Cao J, Wang J. Nanoenabled reversal of IDO1-Mediated immunosuppression synergizes with immunogenic chemotherapy for Improved Cancer Therapy. Nano Lett. 2019;19:5356–65.
Esmaily M, Masjedi A, Hallaj S, Nabi Afjadi M, Malakotikhah F, Ghani S, Ahmadi A, Sojoodi M, Hassannia H, Atyabi F, et al. Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine. J Control Release. 2020;326:63–74.
Masjedi A, Ahmadi A, Ghani S, Malakotikhah F, Nabi Afjadi M, Irandoust M, Karoon Kiani F, Heydarzadeh Asl S, Atyabi F, Hassannia H, et al. Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy. Volume 29. Nanomedicine: NBM; 2020. p. 102240.
Das M, Shen L, Liu Q, Goodwin TJ, Huang L. Nanoparticle delivery of RIG-I agonist enables effective and safe adjuvant therapy in pancreatic Cancer. Mol Ther. 2019;27:507–17.
Qiao C, Yang J, Shen Q, Liu R, Li Y, Shi Y, Chen J, Shen Y, Xiao Z, Weng J, Zhang X. Traceable nanoparticles with dual targeting and ROS response for RNAi-Based immunochemotherapy of Intracranial Glioblastoma Treatment. Adv Mater. 2018;30:e1705054.